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Page 6A TV TIME East Oregonian Wednesday, February 15, 2017 No designer babies, but gene editing to avoid disease? Maybe By LAURAN NEERGAARD AP Medical Writer WASHINGTON — Don’t expect designer babies any time soon — but a major new ethics report leaves open the possibility of one day altering human heredity to fight genetic diseases, with stringent oversight, using new tools that precisely edit genes inside living cells. What’s called genome editing already is trans- forming biological research, and being used to develop treatments for patients struggling with a range of diseases. The science is nowhere near ready for a huge next step that raises ethical ques- tions — altering sperm, eggs or embryos so that babies don’t inherit a disease that runs in the family, says a report Tuesday from the National Academy Gene editing within a living cell A technique called CRISPR-Cas9 is one method of what is called genome editing, allowing scientists to precisely repair or modify genes in the quest for new ways to treat or prevent inherited diseases. Guide RNA Scientists customize RNA molecules to guide an enzyme named Cas9 to the correct spot. Cas9 The enzyme precisely cuts DNA like scissors. The cell repairs itself or a new piece of DNA can be inserted. RNA Edited DNA SOURCE: University of California, Berkeley of Sciences and National Academy of Medicine. But if scientists learn how to safely pass alterations of the genetic code to future generations, the panel said “germline” editing could be attempted under strict AP criteria, including that it targets a serious disease with no reasonable alterna- tive and is conducted under rigorous oversight. “Caution is absolutely needed, but being cautious does not mean prohibition,” said bioethicist R. Alta Charo of the University of Wisconsin-Madison. “This committee is not saying we will or should do germline — heritable — editing. What we are saying is that we can identify a set of strict conditions under which it would be permis- sible to do it,” Charo added. “But we are far, far away from being ready to try.” Genome editing should not go beyond healing the sick and enhance traits such as physical strength, what’s commonly called “designer babies,” the panel stressed. But the public should get involved in these debates now, to say what might one day be acceptable. The long-awaited report offers advice — the presti- gious academies cannot set policy. But it is considered a step toward creating international norms for responsible development of this powerful technology. The U.S. National Acad- emies and its counterparts in Britain and China have been holding international meetings with the hope of doing just that. “Genome editing is a new tool for gene therapy and it has tremendous promise,” Charo said. But, she added, it has to be pursued in a way that promotes well-being and is responsible, respectful and fair. Genome editing is essen- tially a biological version of cut-and-paste software, allowing scientists to turn genes on or off, repair or modify them inside living cells. There are a few older methods but one with the wonky name CRISPR-Cas9 is so much faster, cheaper and simpler to use that it has spurred an explosion of research. Under development are ways to treat a range of Wednesday Morning 6 AM PBS ABC NBC CBS FOX STATION 6:30 AgDay Hot/ Cleve. Good Day Oregon at 6 News News KOIN 6 News at 6 a.m. Wake Up Northwest KGW News at Sunrise Northwest Northwest KATU News Morning Stretch W.L.Yoga (31) KTNW Jet Go! (59) OPB 13 Power 11 KPTV 3 (19) KEPR 2 KOIN 19 (25) KNDU 6 KGW 8 (42) KVEW 4 KATU 5 (11) KFFX diseases from sickle cell and hemophilia to cancer. In lab experiments using human cells or animals engineered with humanlike disorders, scientists are unraveling how gene defects fuel disease — and are even trying to grow transplantable human organs inside pigs. That kind of research is very promising, is adequately regulated today and should continue at full speed, the National Acade- mies panel concluded. When it comes to the more sci fi-sounding uses, it’s quite possible scientists will learn how to perform germline editing in five to 10 years, said panel co-chair Richard Hynes of the Massachusetts Institute of Technology. Safety is one reason for caution, he said, as scientists will have to learn whether editing one gene has unwanted down- stream effects. February 15, 2017 Movies 7 AM 7:30 8 AM 8:30 Good Day Good Day Oregon CBS This Morning (N) CBS This Morning (N) Today Show Tracy Morgan, Gwen Stefani (N) Today Show Tracy Morgan, Gwen Stefani (N) Good Morning America (N) Good Morning America (N) Wild Kratts Jet Go! Nature Cat C.George Nature Cat C.George D.Tiger D.Tiger 9 AM 9:30 Paid Brain Good Day Harry (N) Let's Make a Deal Today Show II (N) Today Show II (N) Live! With Kelly (N) AM Northwest D.Tiger Thomas SplashB. Sesame St. 10 AM 10:30 Steve Harvey The 700 Club The Price Is Right The Price Is Right Today Show III (N) Today Show III (N) The View The View Sesame St. Sesame St. DinoTrain Peg + Cat 11 AM 11:30 Crime Watch Daily Rachael Ray (N) Young & Restless Young & Restless Million? Million? Portland Today Paid Middle Live! With Kelly (N) SplashB. Sit and Fit SuperW! Bob Build AFTERNOON 12 PM FOX (11) KFFX KPTV CBS (19) KEPR KOIN NBC (25) KNDU Inside Action News at Edition 2 6:00 p.m. KOIN Local 19 6 at 6 Local News 6 Evening News Family Feud KVEW KATU 5 (42) ABC 6:30 Modern Modern Family Family 11 "Caught in "Princess the Act" Party" 6 O'Clock News 3 KGW News at 6:00 8 p.m. Extra Local News at 4 6:30 KGW KATU News at 6 PBS NewsHour (31) PBS for senior North Koreans, Gause said. Mark Tokola, vice presi- dent of the Korea Economic Institute in Washington and a former deputy chief of mission at the U.S. Embassy in Seoul, said it would be surprising if Kim Jong Nam was not killed on the orders of his brother, given that North Korean agents have reportedly tried to assassi- nate Kim Jong Nam in the past. “It seems probable that the motivation for the murder was a continuing sense of paranoia on the part of Kim Jong Un,” Tokola wrote in a commentary Tuesday. Although there was scant evidence that Kim Jong Nam was plotting against the North Korean leader, he provided an alternative for North Koreans who would want to depose his brother. The reported killing came as North Korea celebrated its latest missile launch, which foreign experts were analyzing for evidence of advancement in the coun- try’s missile capabilities. For the next several days, North Korea will be marking the birthday of its late leader Kim Jong Il, the brothers’ father, though they have different mothers. The major holiday this Thursday is called the “Day of the Shining Star” and will be feted with figure skating and synchronized swimming exhibitions, fireworks and mass rallies. Since taking power in late 2011, Kim Jong Un has executed or purged a slew of high-level government offi- cials. The most spectacular was the 2013 execution by anti-aircraft fire of his uncle, Jang Song Thaek, once considered the country’s second-most-powerful man. Gause said Kim Jong Nam had been forthright that he did not have political ambitions, although he was publicly critical of the North Korean regime and his brother’s legitimacy in the past. Kim Jong Nam had been less outspoken since 2011, when North Korean assassins reportedly tried to shoot him in Macau, Gause said, though the details of the attempted killing are murky. South Korea also reportedly jailed a North Korean spy in 2012 who admitted to trying to organize a hit-and-run accident targeting Kim Jong Nam in China in 2010. 6 PM STATION KTNW (59) OPB Journeys 13 in Japan Business (N) 6 PM 6:30 STATION PEN 1 PM 1:30 Divorce Divorce Wendy Williams The Talk (N) The Talk (N) Days of Our Lives Days of Our Lives General Hospital General Hospital Meals F&Porter Charlie Rose (N) 2 PM 2:30 Judge Mathis The Dr. Oz Show Let's Make a Deal The Doctors Hot Bench Hot Bench T.D. Jakes (N) The Doctors Harry (N) Stretch C.George Nature Cat Thomas 3 PM 3:30 The People's Court TMZ Live! Dr. Phil Dr. Phil Wendy Williams Ellen DeGeneres (N) Rachael Ray (N) Afternoon Live Speaks WordGirl Cat/ Hat Jet Go! 4 PM 4:30 2½Men Mike&M. 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Wheel of Goldberg Speechless Fortune (N) (N) BBC World WealthT- Nature "Spy in the Wild: Friendship" (N) News rack PBS NewsHour Nature "Spy in the Wild: Friendship" (N) 7:30 9:30 Star "Mama's Boy" (N) FOX News :35 Law & Order: Criminal Intent First at Ten "Palimpsest" Live at Seven Entertai- nment Tonight 7 PM 9 PM Lethal Weapon "As Good as It Getz" (N) 8 PM 8:30 9 PM 9:30 Chicago P.D. "Seven Indictments" (N) City in the Sky "Airborne" (N) 9 Months That Made You "One of a Kind" 10 PM 10:30 11 O'Clock News Action News at 11:00 p.m. KOIN 6 News/ 11 Local News Manage- ment :35 Stephen Colbert :35 S. Colbert :35 The Tonight Show Mystery of Matter "Unruly Elements" 11 PM 11:30 Duck Duck Duck Duck Duck :05 Duck Dynasty "Till :05 Duck :35 Duck The First 48 "Ringside Duck 52 Seat" Dynasty Dynasty Dynasty Dynasty Dynasty Dynasty Duck Do Us Part" Dynasty Dynasty < ++++ The Shawshank Redemption (‘94, < +++ True Grit (‘10, Adv) Jeff Bridges. A 14-year-old girl < +++ Walk the Line (‘05, Bio) AMC 60 Dra) Morgan Freeman, Tim Robbins. enlists a U.S. marshal to help her capture her father's killer. Joaquin Phoenix. Treehouse Masters Treehouse Masters Tree. Mast: Branched "Texas Two Step" (N) Insane Pools DeepEnd ANPL 24 Treehouse Masters < ++ Failure to Launch (‘06, Com) Matthew McConaughey. Roseanne Roseanne Roseanne Roseanne CMT 43 < ++ Failure to Launch Blue (N) Blue Collar Shark Tank Shark Tank Blue Collar Blue Collar Paid Paid CNBC 72 Shark Tank CNN Tonight Anderson Cooper 360 Anderson Cooper 360 CNN Tonight CNN 68 Anderson Cooper 360 CNN Tonight Bush People (N) Bering Sea Gold (N) Alaskan Bush People DISC 51 Alaskan Bush People Alaskan Bush People Alaskan Bush (N) Bizaard. Underc. Good Luck StuckMid Good Luck Liv Maddie Liv Maddie Bunk'd Bunk'd Jessie Jessie DISN 26 Bunk'd NBA NBA Basketball New York Knicks at Oklahoma City Thunder SportsCenter SportsCenter SportsCenter ESPN 33 Basket. (L) Site: Chesapeake Energy Arena -- Oklahoma City, Okla. (L) SportsCenter 30Shorts NFL Live Basketball NBA Basketb. N.Y./Okl. ESPN2 34 NCAA Basketball Duke at Virginia (L) The O'Reilly Factor TuckerCarlsonTonight Hannity The First 100 Days FNC 66 TuckerCarlsonTonight Hannity Cooks vs. Cons Cooks vs. Cons Cooks vs. Cons (N) Bakers vs. Fakers (N) Bakers vs. Fakers FOOD 61 Cooks vs. Cons < ++ Zookeeper (‘11, Com) Kevin James. < ++ Free Willy (‘93, Fam) Lori Petty, Jason James Richter. The 700 Club FREE 32 Middle < ++++ Guardians of the Galaxy (‘14, Adv) Chris Pratt. Legion "Chapter 2" (N) Legion "Chapter 2" FX 65 < X-Men: Days of Future Past LPGA Golf GOLF 88 LPGA Golf Australian Open Round 1 Site: Royal Adelaide Golf Club -- Seaton, Australia (L) Divided Fam. Feud Fam. Feud Baggage Baggage GSN 76 Divided (N) Divided (N) Fam. Feud Fam. Feud Fam. Feud Fam. Feud Divided Middle Middle Middle G. Girls G. Girls HALL 87 Last Man Last Man Last Man Last Man Last Man Last Man Middle Buying and Selling Property Brothers Property Brothers (N) H.Hunt House Property Brothers HGTV 62 Buying and Selling Six "Collateral" Navy SEALs: America's Secret Warriors Pt. 1 of Navy SEALs: America's Secret Warriors Pt. 2 of Six "Collateral" (N) HIST 50 2 cont'd next 2 from Feb 8 (N) Black Magic (N) Little Women: Atlanta LIFE 29 LittleW. "Just a Friend" Little Women: Atlanta Little Women ATL (N) LW Atlanta (N) GShakers Full House Full House Full House Full House Friends Friends NICK 27 H.Danger H.Danger Thunder Thunder Ride Snow Charlie Flag UFC Unleashed "UFC UFC Main UFC Fight Fight Sports MMA Fight: Kickboxing Wild ROOT 37 Motion Places (N) Moore Football Strawweights" Event Flashback < +++ The Dark Knight Rises (2012, Action) < ++ RoboCop (‘14, Act) Joel Kinnaman. A cop is transformed into a < +++ The Book of SPIKE 42 Christian Bale, Tom Hardy, Anne Hathaway. crime-fighting cyborg, but memories of his past life remain. Eli Denzel Washington. The Magicians (N) The Expanse (N) < Oz the Great & Po... SYFY 67 :20 < ++ Mission: Impossible III (‘06, Act) Tom Cruise. Conan (N) Seinf. "The Seinf. "The Seinf. "The Seinf. "The Big Bang Big Bang Big Bang Big Bang Big Bang Full TBS 59 Cartoon" Strongbox" Wizard" Burning" Theory Theory Theory Theory Theory Frontal (N) < The Lost :45 < ++++ Love Affair (1939, Romance) < +++ Love Me or Leave Me (‘55, Biography) :45 < ++++ Lust for Life (‘56, TCM 56 Weekend Irene Dunne, Maria Ouspenskaya, Charles Boyer. James Cagney, Cameron Mitchell, Doris Day. Bio) Anthony Quinn, Kirk Douglas. Too Close to Home (N) 600-lb "Diana's Story" TLC 49 600-lb "Erica's Story" 600-lb "Erica's Story" My 600-lb Life "Diana's Story" (N) Bones < ++ Bad Boys II (‘03, Action) Will Smith, Jordi Mollà, Martin Lawrence. Hawaii Five-0 TNT 57 Bones Noticiero La rosa de Guadalupe Pequeños Gigantes Vino el amor El color de la pasion Impacto Noticie. UNI 21 Incluido NCIS NCIS "Déjà Vu" NCIS "Decompressed" Suits (N) Modern Modern USA 58 NCIS "Cabin Fever" WE 118 < ++ You've Got Mail Meg Ryan. < ++ You've Got Mail (‘98, Rom) Tom Hanks, Meg Ryan. CSI "Come as You Are" CSI "Backstabbers" Cops < ++ The Devil's Advocate (‘97, Susp) Al Pacino, Keanu Reeves. Mother Mother Rules Rules Cops WGN < +++ Jarhead (‘05, Act) Jake Gyllenhaal. :05 < Thirteen Days STZ ENC 644 < Amistad :55 < +++ Philadelphia (‘93, Dra) Tom Hanks. Vice News < +++ Interview With the Vampire Brad Pitt. :05 The Young Pope :05 The Young Pope HBO 518 :05 Eagles of Death The Young Pope LastWeek :35 < Central Intelligence Dwayne Johnson. Movie HBO2 520 < +++ 300 (‘06, Epic) Gerard Butler. :15 < ++ Crossroads (‘02, Dra) Britney Spears. < +++ Rendition Reese Witherspoon. LastWeek Movie HBO3 521 :15 Bill Maher :45 < The Intern (‘15, Com) Robert De Niro. Movie MAX 549 < ++ The Birdcage (‘96, Com) Robin Williams. < Freeheld (‘15, Bio) Ellen Page. :05 < +++ The Hurt Locker Jeremy Renner. SHOW 578 < Love the Coopers (‘15, Com) Diane Keaton. < +++ No Country for Old Men Missing "Come Home" :05 < +++ A Fistful of Dollars :45 < For a Few Dollars More STARZ 621 :05 < +++ Traitor (‘08, Dra) Don Cheadle. A&E CABLE KUALA LUMPUR, Malaysia (AP) — Police were checking surveillance tapes Wednesday for clues about who may have assas- sinated the half-brother of North Korean leader Kim Jong Un at an airport in Kuala Lumpur, a senior official said. An autopsy will also be performed on the body of Kim Jong Nam, police said. Kim, 46, was targeted Monday in the shopping concourse at the airport and had not gone through immi- gration yet for his flight to Macau, said a senior govern- ment official, who spoke on condition of anonymity because the case involves sensitive diplomacy. Kim, who died on the way to a hospital, told medical workers before he died that he had been attacked with a chemical spray, the official said. Selangor police chief Abdul Samah Mat said police were searching for clues in the CCTV footage. The airport is in Selangor near Kuala Lumpur. Kim Jong Nam was estranged from his younger brother, the North Korean leader. Although he had been tipped by some outsiders as a possible successor to his dictator father, others thought that was unlikely because he lived outside the country, including recently in Macau, Singapore and Malaysia. He reportedly fell further out of favor when he was caught trying to enter Japan on a false passport in 2001, saying he wanted to visit Tokyo Disneyland. Multiple South Korean media reports, citing uniden- tified sources, said Kim Jong Nam was killed at the airport by two women believed to be North Korean agents. They fled in a taxi and were being sought by Malaysian police, the reports said. A Malaysian police state- ment confirmed the death of a 46-year-old North Korean man whom it identified from his travel document as Kim Chol, born in Pyongyang on June 10, 1970. Ken Gause, at the CNA think tank in Washington who has studied North Korea’s leadership for 30 years, said Kim Chol was a name that Kim Jong Nam has traveled under. He is believed to have been born May 10, 1971, although birthdays are always unclear 12:30 Paid Pat. Court 12 O'Clock News NameG. Bold & B. News Bold & B. Paid TMZ KGW New Paid The Chew The Chew Charlie Rose (31) KTNW Chef (59) OPB 13 Paint 11 KPTV 3 (19) KEPR 2 KOIN 19 (25) KNDU 6 KGW 8 (42) KVEW 4 KATU 5 EVENING PREMIUM North Korean leader’s brother killed at airport, assailants unknown NIGHT OWL STATION PBS ABC NBC CBS FOX AP Photo/Shizuo Kambayashi, File In this 2001 file photo, a man believed to be Kim Jong Nam, the eldest son of then North Korean leader Kim Jong Il, looks at photographers as he boards a plane to Beijing at Narita international airport in Tokyo. PBS ABC NBC CBS FOX STATION (11) KFFX 12 AM 12:30 :05 Friends :35 Hot In 1 AM :05 CR TV 1:30 2 AM 2:30 3 AM 3:30 4 AM 4:30 5 AM 5:30 CR TV 2 Broke G. TMZ Dish Queens Raising Celeb Paid Paid Minute News Good Day Oregon at 5 S. Colbert :35 James Corden (N) :35 Paid :05 CBS Overnight News News News News S. Colbert :35 James Corden (N) :35 Insider :05 CBS Overnight News News News KOIN 6 News at 5 a.m. Tonight :35 Seth Meyers (N) :35 C. 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