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About Oregon daily emerald. (Eugene, Or.) 1920-2012 | View Entire Issue (Sept. 23, 2002)
*fRUITs* Virgo What are you doing this weekend? Check your PULS0 Longtime Russian head Albert Leong, 66, dies Friends and family remember Albert Leong for his optimism, dedication and gentleness Jillian Daley Family/Health/Education Reporter Recently retired University pro fessor Albert Leong died Aug. 31 of pancreatic cancer. Leong, who was 66, taught Russ ian language, culture and literature at the University from 1966 until 2001, and was also the director of the Russian and East European Studies Center and head of the Russ ian department. Professor Alan Kimball, who knew the man for 35 years, said Leong was responsible both for creating a Russ ian department that stood apart from the other Slavic language pro grams and for co-founding the EESC. Kimball said Leong had a defini tive personality. “He spoke very softly, and yet he was extremely stubborn when it came to pursuing the right goal,” Kimball said. “One of the biggest Courtesy Annette Duke Leong things about him that I remember was his optimism.” Kimball added that Leong could Turn to Leong, page 22A UNIVERSITY OF OREGON MUSEUM OF NATURAL HISTORY Visit the o Museum Y>tore: fast and f*resents for Unique Gifts that Reflect the Natural and Cultural Riches of the Pacific Northwest 1680 East 15th Avenue near Agate Street ■ (541) 346-1809 • Open noon to 5:00 p.m. Tuesday through Sunday Contraceptive Injection medroxyprogesterone acetate injectable suspension B»irtK corvtrol ^ou-tK'n^k aeout jus-t M-xa^ear DEPO-PROVERA' Contraceptive Injection (medroxyprogesterone acetate injectable suspension, USP) This product is intended to prevent pregnancy. It does not protect against HIV infection (AIDS) and other sexually transmitted diseases. What is DEPO-PROVERA Contraceptive Injection? DEPO-PROVERA Contraceptive Injection is a form of birth control that is given as an intramuscular injection (a shot) in the buttock or upper arm once every 3 months (13 weeks). To continue your contraceptive protection, you must return for your next injection promptly at the end of 3 months (13 weeks). DEPO-PROVERA contains medroxyprogesterone acetate, a chemical similar to (but not the same as) the natural hormone progesterone, which is produced by your ovaries during the second half of your menstrual cycle. DEPO-PROVERa acts by preventing your egg cells from ripening. If an egg is not released from the ovaries during your menstrualcycle, it cannot become fertilized by sperm and result in pregnancy. DEPO-PROVERA also causes changes in the lining of your uterus that make it less likely for pregnancy to occur How effective is DEPO-PROVERA Contraceptive Injection? The efficacy of DEPO-PROVERA Contraceptive Injection depends on following the recommended dosage schedule exactly (see "How often do I get my shot of DEPO-PROVERA Contraceptive injection?"). To make sure you are not pregnant when you first get DEPO-PROVERA Contraceptive Injection, your first injection must be given ONLY during the first 5 days of a normal menstrual period; ONLY within the first 5 days after childbirth if not breast-feeding; and, if exclusively breast-feeding, ONLY at the sixth week after childbirth. It is a long-term injectable contraceptive when administered at 3-month (13-week) intervals. DEPO-PROVERA Contraceptive Injection is over 99% effective, making it one of the most reliable methods of birth control available. This means that the average annual pregnancy rate is less than one for every 100 women who use DEPO-PROVERA. The effectiveness of most contraceptive methods depends in part on how reliably each woman uses the method. The effectiveness of DEPO-PROVERA depends only on the patient returning every 3 months (13 weeks) for her next injection. Your health-care provider will help you compare DEPO-PROVERA with other contraceptive methods and give you the information you need in order to decide which contraceptive method is the right choice for you. The following table shows the percent of women who got pregnant while using different kinds of contraceptive methods. It gives both the lowest expected rate of pregnancy (the rate expected in women who use each method exactly as it should be used) and the typical rate of pregnancy (which includes women who became pregnant because they forgot to use their birth control or because they did not follow the directions exactly). Percent of Women Experiencing an Accidental Pregnancy in the First Year of Continuous Use Method DEPO-PROVERA Implants (Norplant) Female sterilization Male sterilization Oral contraceptive (pill) Combined Progestogen only IUD Pnogestasert Copper T 38QA Condom (without spermicide) Diaphragm (with spermicide) Cervical cap Periodic abstinence Spermicide atone Vaginal Sponge used before childbirth used after childbirth No method Lowest Expected Source: Trussell et al. Obstet Gynecol. 1990:76:558-567. •From Norplant* package insert. Who should not use DEPO-PROVERA Contraceptive Injection? Not all women should use DEPO-PROVERA. You should not use DEPO-PROVERA if you have any of the following conditions: • if you think you might be pregnant • if you have any vaginal bleeding without a known reason • if you have had cancer of the breast • if you have had a stroke • if you have or have had blood clots (phlebitis) in your legs • if you have problems with your liver or liver disease • if you are allergic to DEPO-PROVERA (medroxyprogesterone acetate or any of its other ingredients). What other things should I consider before using DEPO-PROVERA Contraceptive Injection? You will have a physical examination before your doctor prescribes DEPO-PROVERA. It is important to tell your health-care provider if you have any of the following: • a family history of breast cancer • an abnormal mammogram (breast x-ray), fibrocystic breast disease, breast nodules or lumps, or bleeding from your nipples • kidney disease • irregular or scanty menstrual periods • high blood pressure • migraine headaches • asthma • epilepsy (convulsions or seizures) • diabetes or a family history of diabetes • a history of depression • if you are taking any prescription or over-the-counter medications This product is intended to prevent pregnancy. It does not protect against transmission of HIV (AIDS) and other sexually transmitted diseases such as chlamydia, genital herpes, genital warts, gonorrhea, hepatitis B, and syphilis. What if I want to become pregnant after using DEPO-PROVERA Contraceptive Injection? Because DEPO-PROVERA is a long-acting birth control method, it takes some time after your last injection for its effect to wear off, Based on the results from a large study done in the United States, for women who stop using DEPO-PROVERA in order to become pregnant, it is expected that about half of those who become pregnant will do so in about 10 months after their last injection; about two thirds of those who become pregnant will do so in about 12 months; about 83% of those who become pregnant will do so in about 15 months; and about 93% of those who become pregnant will do so in about 18 months after their last injection. The length of time you use bEPO-PROVERA has no effect on how lonait takes you to become pregnant after you stop using it. What are the risks of using DEPO-PROVERA Contraceptive Injection? I .Irregular Menstrual Bleeding The side effect reported most frequently by women who use DEPO-PROVERA for contraception is a change in their normal menstrual cycle. During the first year of using DEPO-PROVERA, you might have one or more of the following changes: irregular or unpredictable bleeding or spotting, an increase or decrease in menstrual bleeding, or no bleeding at all. Unusually heavy or continuous bleeding, however, is not a usual effect of DEPO-PROVERA: and if this happens, you should see your hearth care provider right away. With continued use of DEPO-PROVERA, bleeding usually decreases, and many women stop having periods completely. In clinical studies of DEPO-PROVERA, 55% of the women studied reported no menstrual bleeding (amenorrhea) after I year of use, and 68% of the women studied reported no menstrual bleeding after 2 years of use. The reason that your periods stop is because DEPO-PROVERA causes a resting state in your ovaries. When your ovaries do not release an egg monthly, the regular monthly growth of the lining of your uterus does not occur and, therefore, the bleeding that comes with your normal menstruation does not take place. When you stop using DEPO-PROVERA your menstrual period will usually, in time, return to its normal cycle. 2.8one Mineral Changes Use of DEPO-PROVERA may be associated with a decrease in the amount of mineral stored in your bones. This could increase your risk of developing bone fractures. The rate of bone mineral loss is greatest in the early years of DEPO-PROVERA use, but after that, it begins to resemble the normal rate of age-related bone mineral loss. Studies of women who have used different forms of contraception found that women who used DEPO-PROVERA for contraception had no increased overall risk of developing cancer of the breast, ovary, uterus, cervix, or liver However, women under 35 years of age whose first exposure to DEPO-PROVERA was within the previous 4 to 5 years may have a slightly increased risk of developing breast cancer similar to that seen with oral contraceptives. You should discuss this with your health-care provider. 4.Unexpected Pregnancy Because DEPO-PROVERA is such an effective contraceptive method, the risk of accidental pregnancy for women who get their shots regularly (every 3 months [13 weeks]) is very low. while there have been reports of an increased risk of low birth weight and neonatal infant death or other health problems in infants conceived dose to the time of injection, such pregnancies are uncommon. If you think you may have become pregnant while using DEPO-PROVERA for contraception, see your health-care provider as soon as possible. SAIIergic Reactions Some women using DEPO-PROVERA Contraceptive Injection have reported severe and potentially life-threatening allergic reactions known as anaphylaxis and anaphylactoid reactions. Symptoms include the sudden onset of hives or swelling and itching of the skin, breathing difficulties, and a drop in blood pressure. 6.Other Risks Women who use hormone-based contraceptives may have an increased risk of blood clots or stroke. Also, if a contraceptive method fails, there is a possibility that the fertilized egg will begin to develop outside of the uterus (ectopic pregnancy). While these events are rare, you should tell your health-care provider if you have any of the problems listed in the next section. What symptoms may signal problems while using DEPO-PROVERA Contraceptive Injection? Call your health-care provider immediately if any of these problems occur following an injection of DEPO-PROVERA: • sharp chest pain, coughing up of blood, or sudden shortness of breath (indicating a possible clot in the lung) • sudden severe headache or vomiting, dizziness or fainting, problems with your eyesight or speech, weakness, or numbness in an anm or leg (indicating a possible stroke) • severe pain or swelling in the calf (indicating a possible clot in the leg) • unusually heavy vaginal bleeding • severe pain or tenderness In the lower abdominal area • persistent pain, pus, or bleeding at the injection site What are the possible side effects of DEPO-PROVERA Contraceptive Injection? I .Weight. Gain You may experience a weight gain while you are using DEPO-PROVERA. About two thirds of the women who used DEPO-PROVERA in clinical trials reported a weight gain of about 5 pounds during the first year of use. You may continue to gain weight after the first year Women in one large study who used DEPO-PROVERA for 2 years gained an average total of 8.1 pounds over those 2 years, or approximately 4 pounds per year Women who continued for 4 years gained an average total of 13.8 pounds over those 4 years, or approximately 3.5 pounds per year Women who continued for 6 years gained an average total of 16.5 pounds over those 6 years, or approximately 2.75 pounds per year. 2.0ther Side Effects In a clinical study of over 3,900 women who used DEPO-PROVERA for up to 7 years, some women reported the following effects that may or may not have been related to their use of DEPO-PROVERA: Irregular menstrual bleeding, amenorrhea, headache, nervousness, abdominal cramps, dizziness, weakness or fatigue, decreased sexual desire, leg cramps, nausea, vaginal discharge or irritation, breast swelling and tenderness, bloating swelling of the hands or feet, backache, depression, insomnia, acne, pelvic pain, no hair growth or excessive hair loss, rash, hot flashes, and joint pain. Other problems were reported by very few of the women in the clinical trials, but some of these could be serious. These include convulsions, jaundice, urinary tract infections, allergic reactions, fainting paralysis, osteoporosis, lack of return to fertility, deep vein, thrombosis, pulmonary embolus, breast cancer, or cervical cancer If these or any other problems occur during your use of DEPO-PROVERA, discuss them with your health-care provider Should any precautions be followed during use of DEPO-PROVERA Contraceptive Injection? /.Missed Periods During the time you are using DEPO-PROVERA for contraception, you may skip a period, or your periods may stop completely. If you have been receiving your DEPO-PROVERA injections regularly every 3 months (13 weeks), then you are probably not pregnant. However, if you think that you may be pregnant, see your health-care provider. 2.Loboratory Test Interactions If you are scheduled for any laboratory tests, tell your health-care provider that you are using DEPO-PROVERA for contraception. Certain blood tests are affected by hormones such as DEPO-PROVERA. J.Drue Interactions Cytadren (aminoglutethimide) is an anticancer drug that may significantly decrease the effectiveness of DEPO-PROVERA if the two drugs are given during the same time. 4.Nurang Mothers Although DEPO-PROVERA can be passed to the nursing infant in the breast milk, no harmful effects nave been found in these children. DEPO-PROVERA does not prevent the breasts from producing milk, so it can be used by nursing mothers. However to minimize the amount of DEPO-PROVERA that is passed to the infant in the first weeks after birth, you should wait until 6 weeks after childbirth before you start using DEPO-PROVERA for contraception. How often do I get my shot of DEPO-PROVERA Contraceptive Injection? The recommended dose of DEPO-PROVERA is 150 mg every 3 months (13 weeks) given in a single intramuscular injection in the buttock or upper arm. To make sure that you are not pregnant at the time of the first injection, it is essential that the injection be given ONLY during the first 5 days of a normal menstrual period. If used following the delivery of a child, the first inaction of DEPO-PROVERA MUST be given within 5 days after childbirth if you are not breast-feeding or 6 weeks after childbirth if you are exclusively breast-feeding. If you wait longer than 3 months (13 weeks) between injections, or longer than 6 weeks after delivery, your health-care provider should determine that you are not pregnant before giving you your injection of DEPO-PROVERA. Rx only CB-7-S Pharmacia & Upjohn Company Kalamazoo, Ml 49001, USA Pharmacia & Upjohn
