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Nader and LaDuke want your vote so they can work nationally for:
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Tom Patterson Emerald
University Assistant Professor of chemistry Andrew Marcus has created a new way to examine a cell’s behavior using a laser array and
quickly pulsing light, named Fourier Imaging Correlation Spectroscopy.
Cellular science progresses
■ A UO Professor of chemistry
has developed a new, faster
technique to study the
molecular behavior of cells
By Brooke Ross
Oregon Daily Emerald
University Assistant Professor of
chemistry Andrew Marcus has cre
ated a new technique using light to
study cellular materials in an effort
to learn more about the structure
and dynamics of molecular move
ment within cells.
Marcus is using the technique,
which he named Fourier Imaging
Correlation Spectroscopy, to study
mitochondria, which are responsi
ble for movement within the cell
membrane. Mitochondria are im
portant to study because they have
a lot of metabolic processes and
can give knowledge about certain
diseases such as diabetes.“We now
have a faster way to study a cell’s
behavior, which should help push
scientific technology further,”
Marcus said.
The process involves illuminat
ing a cell with a pattern of light
millions of times per second, and
studying the noise created by mo
lecular motion, he said. This noise
helps Marcus interpret cellular be
havior.
Marcus’ work took three years to
complete and is funded by the
University, the National Science
Foundation and the American
Heart Association.
Marcus said there are several ad
vantages to using the FICS tech
nique. One benefit is that it allows
for the observation of molecular
systems within better time resolu
tions. It is now possible to study
proteins, which make up how all
living things work, in microsecond
time scales, he said.
“A lot of biological action hap
pens in this time scale,” Marcus
said.
FICS also allows scientists to
study cells for longer periods of
time without killing them, he said.
The finding is especially impor
tant to the medical field because
using the system makes it easier to
distinguish healthy cells from self
destructing cells, he said, adding
that this knowledge will give phar
maceutical companies and the
health industry added information
about diseases.
Graduate student Michelle
Knowles is also involved in the
FICS research. Knowles, who has
been involved with the work for
over a year, works in Marcus’ lab
and prepares cell slides and ob
serves their movements.
“I hope to see this work carried
out, so we can learn more about
mitochondrial diseases in the fu
ture,” she said.
After developing FICS, Marcus
joined with University professor
Roderick Capaldi, an expert on mi
tochondria, to study the motion of
mitochondria. Marcus said the two
professors have been able to learn
from each other’s areas of expertise.
Several graduate students are
currently involved in the ongoing
research, including Daciana Mar
gineando, who studies the struc
ture of the cell’s membrane in Ca
paldi’s lab.
“We’ve done the underground
work, but now we want to address
the biological questions,” she said.
Margineando works with a more
traditional imaging technique
called digital video fluorescence
microscopy, which allows her to
see the structures and observe the
position of the mitochondria. By
using both techniques, the re
searchers are able understand not
only what the mitochondria look
like, but what they are doing.
She hopes to see the research be
come more thorough so it will be
possible to study the inside of oth
er cell elements in order to under
stand the dynamics of cellular
structures.
Oregon Daily Emerald
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