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About Oregon daily emerald. (Eugene, Or.) 1920-2012 | View Entire Issue (Nov. 21, 1961)
$17,145 grant given for cancer research The National Cancer Institute has awarded a $17,145 grant In sixth-year support of a Univer sity project to synthesize a ma terial that destroys cancer cells. Ia-llOY II. KLKMM, associate professor of chemistry, Is direc tor of the project and the grant, which will be effective Dec. 1. A similar amount 1s promised for 1962-83. Klemm is trying to make or ganic chemical compounds which have similarities in chemical sti ucture to a naturally-occur ring material obtained from the may apple root, a plant that grows In the woods of Oregon and the Midwest. The material is called podophyllotoxin. ABOUT 1947, It was acciden tally discovered that podophyllo toxin would destroy cancerous cells but not harm normal cells In a test tube. Clinical trials in-' cheated, however, that the ma-, terial was too toxic it killed the tumor and the host. In Klemm’# project, n com pound is being sought that has similar tumor-inhibiting action but with the toxicity eliminated, j Research along these lines was started in 1954. “THIS KAIC. we have not been Give your parents and friends a Gift they will Cherish A Christmas Portrait the FEHLY STUDIO “On the Campus” DI 4-3432 1214 Kincaid successful In getting the exact compound that wt are looking for, but we have obtained one other substance which has prop erties very similar to podophyllo-^ toxin,” Klemm said. This substance is being tested at present by the National Can cer Service Center, which has lab oratories across the countr y. Tests, in animals, are being made against three types of cancer: leukemia, sarcoma, and carci noma. HINCK 1959 Kiemrn has used ultraviolet light as an important step in the latioratory procedure to synthesize compounds similar to podophyllotoxin. Podophyllotoxin is one of a group of compounds occurring in plants that come under the name lignans. Only a small number of ilgnans have tumor-inhibiting properties. THIS tumor inhibition. Klemm said, seems to be connected with the over-all three-dimensional structure of the molecule. Those like podophyllotoxin have a right angular structure. In the procedure, Klemm takes a long, thin, ribbon-shaped mole cule that doubles back on itself. The molecule Is made of hydro gen. and carbon. I I/TKAVIOLKT rays arc used to pinch the ribbon molecule to gether and to bend it upward to produce the angular structure. The band Is clamped together in two places at the same time. Klemm is working on another project under support from the National Cancer Institute to pro duce artificial cancer by chemi cal means. A greater understand ing of cancer is being sought by discovering the three-dimensional geometry of the cancer progress. I'.VOEK A third project re lated to the first two. Klemrn is working on the geometry of or ganic chemical reactions on sur faces. This project is supported by an Air Force grant. Klemm also is director of the National Science Foundation un dergraduate chemistry program. Conviction upheld MONTGOMERY, Ala. (UPIi An appeals court in Montgomery, Ala., has upheld the conviction of four white university profes sors and seven Negro integra tion leaders. They were charged with dis orderly conduct for trying to eat together in an all-white bus sta tion restaurant. Infirmary Attempting ipeedy recoveries t<> eitjnv holtda> inn ate Jerry Ann Babcock, l*;t tricia Hoff, Joanne 11 inn, Virginia Becker, MikHI Thurston. Herald Hurley, Andre Kcrnbokn, Robert Kennedy. Richard Sev ertson, Phillip Poster, Hcrold Hymen, Richard Reed, Herald Krdman. Brian Mitchell, and Roger Newell. i Don Clark Sigma Nu President says: "Check the Chick(en) at THE com DRUMSTICK Special—5 Char-glo Burgers to go—99c Open every day 6 a.m.-l 1 p.m. 774 E. 11th Infirmary to close The .Student Health Service Hill he closed Thursday. It will lie open from 10 a.m. to 11:30 a.m. Friday and Saturday for KMKIMiKNCY cases only! The doctor will be In at this time. Bryan to deliver lecture on Finland Architecture of Finland and the Great White City in the North will be discussed in a slide lecture by Stanley W'. Bryan, as sociate professor of architecture, at H p.m. tonight in room 100 Science. An exhibit of the arts and crafts of Finland and phot o graphs of old wood and masonry country churches will be shown in the lobby of Lawrence Hall. Bryan spent nine months in in Finland as a Fulbright Re search Scholar last school year. Most of this period was spent in the capitol city of Helsinki, but he also took lecture tours to smaller cities in the North. Algerian strike ends PARIS (UPI i French offi cials said Moslem Algerian pris oners have ended their 19-day hunger strike under a "compro mise" agreement. Earlier Monday thousands of Algerian prisoners ended sympathy hunger strikes after they were guaranteed treat ment as political, rather than criminal prisoners. Use Emerald Classified Ads— Phone DI 2-1411, Ext. 61S. II. I.. A. HART, % isiting leeturer at the University from Oxford, will speak today. You always SAVE at Pride of Oregon GAS FOR LESS Pride of Oregon Your Pay Less—Go Farther Gas Station STUDENTS ... if you and your family are in Eugene for the holidays . . . JL WILL BE SERVING COMPLETE THANKSGIVING DINNERS • TURKEY with all the trimmings, S2.00 ALSO OTHER DELICIOUS SELECTIONS AT THE SAME PRICE Open Weekends Including Thanksgiving Day at Noon. Sat. & Sun. at 4 p.m. for Reservations Call Rl 6-9207 5094 Mam, Springfield SIC FLICS 1 “Every fraternity needs some kind of mascot...” 21 GREAT TOBACCOS MAKE 20 Y/ONDERFUL SMOKES! AGED MILD. BLENDED MILD - NOT FILTERED MILD -THEY SATISFY
