SIUSLAW NEWS | WEDNESDAY, JULY 21, 2021 | 7B
Treating “Untreatable” Cancers:
Functional Profi ling Comes of Age
Hey Graphic Searchers
Please submit your entry for a chance to win
a gift certifi cate:
(NAPSI)—Over 1.8 mil-
lion Americans are diag-
nosed with cancer every
year according to the Amer-
ican Cancer Society. If you
or someone you care about
is diagnosed with cancer
you may be relieved to
know there are techniques
available that can improve
your likelihood of response
and survival by using your
cancer cells to select the
most effective drugs before
you receive them.
What Can Help
The process is called
functional profi ling, which
analyzes living cancer cells
from a patient to fi nd out
the drugs, combinations
and sequences that are
the most effective and least
toxic for each individual. It’s
particularly helpful in treat-
ing cancers that have been
considered “untreatable,”
such as pancreatic can-
cers, advanced lung and
recurrent breast cancers.
Why It Works
Cancers arise from cells
that have learned certain
tricks to enhance their sur-
vival. In so doing they out-
live their normal counter-
parts. These transformed
cells interact directly with
their micro-environment.
Cancer cells “talk” to each
other and to all the sur-
rounding immune cells,
blood vessels and struc-
tural elements using chem-
ical signals such as growth
fac- tors and metabolic
byproducts. Blood vessels,
immune cells and connec-
tive tissues all participate
and promote the cancer
process.
Each human cancer re-
fl ects all of its genes, both
mutated and normal, acting
together to create what we
recognize as a malignant
tumor. But gene changes
are only the starting point
and not the fi nal product
of cancer development.
The practice of just ana-
lyzing genes is incapable
of capturing the complexity
of human tumor biology.
Only Functional analyses
can interrogate each pa-
tient’s tumor in real time
to provide insights that can
inform drug selection and
treatment decisions.
Because each cancer
patient is unique and very
different from one person
to the next, drugs that work
for one person may not
for another, even with ex-
actly the same diagnosis.
Standard
trial-and-error
approaches cannot meet
each patient’s needs.
Who Developed the Idea
The pioneer behind this is
Los Angeles-based oncolo-
gist Dr. Robert Nagourney,
author of “Outliving Cancer”
and known as the father of
precision cancer medicine.
His testing of cancer cells
against potential drugs
offers patients the opportu-
nity to take charge of their
cancers and the treatments
most likely to work.
Dr. Nagourney recog-
nized the short comings of
modern trial and error can-
cer medicine and decided
to do something about it.
Over the past two decades
he has amassed data on
over 10,000 patients, pro-
viding individualized thera-
pies that have been shown
to double response rates
and improve survival. While
major centers continue to
offer gene profi les that ex-
amine DNA mutations hop-
ing to fi nd a “magic bullet,”
those result have been ex-
tremely disappointing with
a minority of patient’s re-
vealing actionable fi ndings.
Get Help
The Nagourney Institute
receives samples from all
over the world. If you think
functional profi ling would
be good for you, you can
arrange to have your sam-
ple collected and shipped
overnight to the laboratory.
The Institute will even as-
sist you with a specimen
transportation kit and spe-
cifi c handling instructions.
Learn More
For further facts and
to arrange for tests, visit
https://www.nagourneycan-
cerinstitute.com.
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