OREGON S LGBTO N EW S M A G A ZIN E
• medicines for tuberculosis (TB), such as rifabutin
(Mycobutin®)
• inhaled steroid medicines, such as fluticasone
propionate (Flonase®)
• inhaled medicines such as salmeterol (Serevent®)
or salmeterol in combination with fluticasone
propionate (Advair®). Your doctor may need to
change to a different medicine
• medicines for gout, such as colchicine (Colcrys®)
• medicines to treat pulmonary arterial hypertension
(PAH), such as bosentan (Tracleer®) or tadalafil
(Adcirca®)
• pain medicines, such as fentanyl (Duragesic®,
lonsys™, Fentora®) and methadone
If you are not sure if you are taking a medicine
above, ask your doctor.
How should»take KALETRA?___________
FEBRUARY 18. 2011
• When your KALETRA supply starts to run low, get
more from your doctor or pharmacy. It is important
not to run out of KALETRA. The amount of HIV-1 virus
in your blood may increase if the medicine is stopped
for even a short time. The virus may become resistant
to KALETRA and become harder to treat.
• KALETRA can be taken with acid reducing agents
used for heartburn or reflux such as omeprazole
(Prilosec®) and ranitidine (Zantac®) with no dose
adjustment.
• KALETRA should not be administered once daily in
combination with carbamazepine (Tegretol® and
Epitol®), phénobarbital (Luminal®), or phenytoin
(Dilantin®).
Avoid doing things that can spread HIV infection.
KALETRA does not stop you from passing HIV infection
to others. Do not share needles, other injection
equipment or personal items that can have blood
or body fluids on them, like toothbrushes and razor
blades. Always practice safer sex by using a latex or
polyurethane condom to lower the chance of sexual
contact with semen, vaginal secretions, or blood.
• Take KALETRA every day exactly as prescribed by
your doctor.
• It is very important to set up a dosing schedule and
follow it every day.
• Do not change your treatment or stop treatment
What are the possible side effects of
without first talking with your doctor.
KALETRA?_____________________________
• Swallow KALETRA tablets whole. Do not chew,
break, or crush KALETRA tablets.
KALETRA can cause serious side effects.
• KALETRA tablets can be taken with or without food.
• See “What is the most important information i
• If you are taking both Videx® (didanosine) and
should know about KALETRA?”
KALETRA:
• Liver problems. Liver problems, including death,
o didanosine can be taken at the same time as
can happen in people who take KALETRA. Blood tests
KALETRA tablets, without food,
in people who take KALETRA may show possible
o take didanosine either one hour before or two
liver problems. People with liver disease such as
hours after taking KALETRA oral solution.
Hepatitis B and Hepatitis C who take KALETRA may
• Do not miss a dose of KALETRA. This could make the
have worsening liver disease. Tell your healthcare
virus harder to treat. If you forget to take KALETRA,
provider right away if you have any of these signs and
take the missed dose right away. If it is almost time
symptoms of liver problems:
for your next dose, do not take the missed dose.
o loss of appetite
Instead, follow your regular dosing schedule by
o yellow skin and whites of eyes (jaundice)
taking your next dose at its regular time. Do not take
o dark-colored urine
more than one dose of KALETRA at one time.
o pale colored stools, itchy skin
• If you take more than the prescribed dose of
o stomach area (abdominal) pain.
KALETRA, call your local poison control center or
• Inflammation of the pancreas (pancreatitis).
emergency room right away.
Some people who take KALETRA get inflammation of
• Take KALETRA oral solution with food to help it work
the pancreas which may be serious and cause death.
better.
You have a higher chance of getting pancreatitis if
• If KALETRA is being used for your child, tell your
you have had it before. Tell your doctor if you have
doctor if your child’s weight changes.
nausea, vomiting, or abdominal pain while taking
• KALETRA should not be given one time each day in
KALETRA. These may be signs of pancreatitis.
children. When giving KALETRA to your child, give
• Increases in certain fat (triglycerides and
KALETRA exactly as prescribed.
cholesterol) levels in your blood. Large increases
• KALETRA oral solution contains a large amount of
of triglycerides and cholesterol can be seen in blood
alcohol.
test results of some people who take KALETRA.
o If a young child drinks more than the
The long-term chance of getting complications
recommended dose, it could make them sick from
such as heart attacks or stroke due to increases in
too much alcohol. Contact your local poison control
triglycerides and cholesterol caused by protease
center or emergency room right away,
inhibitors is not known at this time.
o Talk with your doctor if you take or plan to take
• Diabetes and high blood sugar (hyperglycemia).
metronidazole or disulfiram. You can have severe
Some people who take protease inhibitors including
nausea and vomiting if you take these medicines
KALETRA get new or more serious diabetes, or high
with KALETRA.
blood sugar. Tell your doctor if you notice an increase
in thirst or urinate often while taking KALETRA.
• Changes in body fat. Changes in body fat in
some people who take antiretroviral therapy. These
changes may include increased amount of fat in the
upper back and neck (“ buffalo hump”), breast, and
around the trunk. Loss of fat from the legs, arms
and face may also happen. The cause and long-term
health effects of these conditions are not known at
this time.
• Increased bleeding for hemophiliacs. Some
people with hemophilia have increased bleeding
with protease inhibitors including KALETRA.
• Increased risk of certain problems when you
take medicines used for the treatment of
erectile problems such as sildenafil (Viagra* *),
tadalafil (Cialis®). or vardenafil (Levitra®) with
KALETRA:
° low blood pressure. If vou get dizzy or faint, you
need to lie down. Tell vour doctor if you feel dizzy,
or have fainting spells.
^ vision changes. Tell vour doctor right awav if vou
have vision changes.
penis erection lasting more than 4 hours. If vou
are a male and have an erection that lasts longer
than 4 hours, get medical help right awav to avoid
permanent damage to vour penis. Your doctor can
explain these symptoms to vou.
• Allergic reactions. Skin rashes, some of them
severe, can occur in people who take KALETRA. Tell
your healthcare provider if you had a rash when you
took another medicine for your HIV infection or if you
notice any skin rash when you take KALETRA.
Common side effects of KALETRA include:
• diarrhea
• nausea
• stomach area (abdominal) pain
• feeling weak
• vomiting
• headache
• upset stomach
These are not all of the possible side effects of
KALETRA. For more information, ask your doctor or
pharmacist. Tell your doctor about any side effect that
bothers you or that does not go away.
Call your doctor for medical advice about side effects.
You may report side effects to FDA at 1 -800-FDA-
1088._______________________________________
How should i store KALETRA?
KALETRA tablets:
• Store KALETRA tablets at room temperature,
between 59°F to 86°F (15°C to 30°C).
• Do not keep KALETRA tablets out of the container
it comes in for longer than 2 weeks, especially in
areas where there is a lot of humidity. Keep the
container closed tightly.
KALETRA oral solution:
• Store KALETRA oral solution in a refrigerator,
between 36°F to 46°F (2°C to 8°C). KALETRA oral
solution that is kept refrigerated may be used until
the expiration date printed on the label.
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