Just out., October 15, 2010, Page 9, Image 9

O REGO N S LE SB IAN/GAY/B l/TRAN S/QUE E R NEWSMAGAZINE
• medicines for tuberculosis (TB), such as rifabutin
(Mycobutin®)
• inhaled steroid medicines, such as fluticasone
propionate (Flonase®)
• inhaled medicines such as salmeterol (Serevent®)
or salmeterol in combination with fluticasone
propionate (Advair®). Your doctor may need to
change to a different medicine
• medicines for gout, such as colchicine (Colcrys®)
• medicines to treat pulmonary arterial hypertension
(PAH), such as bosentan (Tracleer®) or tadalafil
(Adcirca®)
• pain medicines, such as fentanyl (Duragesic®,
lonsys™, Fentora®) and methadone
If you are not sure if you are taking a medicine
above, ask your doctor.
OCTOBER 15 2010 9
• When your KALETRA supply starts to run low, get
more from your doctor or pharmacy. It is important
not to run out of KALETRA. The amount of HIV-1 virus
in your blood may increase if the medicine is stopped
for even a short time. The virus may become resistant
to KALETRA and become harder to treat.
• KALETRA can be taken with acid reducing agents
used for heartburn or reflux such as omeprazole
(Prilosec®) and ranitidine (Zantac®) with no dose
adjustment.
• KALETRA should not be administered once daily in
combination with carbamazepine (Tegretol® and
Epitol®), phénobarbital (Luminal®), or phenytoin
(Dilantin®).
Avoid doing things that can spread HIV infection.
KALETRA does not stop you from passing HIV infection
to others. Do not share needles, other injection
equipment or personal items that can have blood
or body fluids on them, like toothbrushes and razor
blades. Always practice safer sex by using a latex or
polyurethane condom to lower the chance of sexual
contact with semen, vaginal secretions, or blood.
• Changes in body fat. Changes in body fat in
some people who take antiretroviral therapy. These
changes may include increased amount of fat in the
upper back and neck (“ buffalo hump”), breast, and
around the trunk. Loss of fat from the legs, arms
and face may also happen. The cause and long-term
health effects of these conditions are not known at
this time.
• Increased bleeding for hemophiliacs. Some
people with hemophilia have increased bleeding
with protease inhibitors including KALETRA.
• Increased risk of certain problems when you
take medicines used for the treatment of
erectile problems such as sildenafil (Viagra®),
tadalafil (Cialis®^ or vardenafil (Levitra®) with
KALETRA:
o low blood pressure. If you get dizzy or faint, you
How should I take KALETRA?___________
need to lie down. Tell vour doctor if you feel dizzy,
or have fainting spells.
• Take KALETRA every day exactly as prescribed by
your doctor.
vision changes. Tell vour doctor right away if you
have vision changes.
• It is very important to set up a dosing schedule and
follow it every day.
° penis erection lasting more than 4 hours. If you
are a male and have an erection that lasts longer
• Do not change your treatment or stop treatment
What
are
the
possible
side
effects
of
without first talking with your doctor.
than 4 hours, get medical help right away to avoid
KALETRA?_____________________________
permanent damage to vour penis. Your doctor can
• Swallow KALETRA tablets whole. Do not chew,
explain these symptoms to you.
break, or crush KALETRA tablets.
KALETRA can cause serious side effects.
• Allergic reactions. Skin rashes, some of them
• KALETRA tablets can be taken with or without food.
• See “What is the most important information I
severe, can occur in people who take KALETRA. Tell
• If you are taking both Videx® (didanosine) and
should know about KALETRA?”
your healthcare provider if you had a rash when you
KALETRA:
• Liver problems. Liver problems, including death,
took another medicine for your HIV infection or if you
o didanosine can be taken at the same time as
can happen in people who take KALETRA. Blood tests
notice any skin rash when you take KALETRA.
KALETRA tablets, without food,
in people who take KALETRA may show possible
o take didanosine either one hour before or two
Common side effects of KALETRA include:
liver problems. People with liver disease such as
hours after taking KALETRA oral solution.
• diarrhea
Hepatitis B and Hepatitis C who take KALETRA may
• Do not miss a dose of KALETRA. This could make the
• nausea
have worsening liver disease. Tell your healthcare
virus harder to treat. If you forget to take KALETRA,
provider right away if you have any of these signs and • stomach area (abdominal) pain
take the missed dose right away. If it is almost time
• feeling weak
symptoms of liver problems:
for your next dose, do not take the missed dose.
• vomiting
o loss of appetite
Instead, follow your regular dosing schedule by
• headache
° yellow skin and whites of eyes (jaundice)
taking your next dose at its regular time. Do not take
• upset stomach
o dark-colored urine
more than one dose of KALETRA at one time.
o pale colored stools, itchy skin
These are not all of the possible side effects of
• If you take more than the prescribed dose of
o stomach area (abdominal) pain.
KALETRA. For more information, ask your doctor or
KALETRA, call your local poison control center or
• Inflammation of the pancreas (pancreatitis).
pharmacist. Tell your doctor about any side effect that
emergency room right away.
Some people who take KALETRA get inflammation of
bothers you or that does not go away.
• Take KALETRA oral solution with food to help it work
the pancreas which may be serious and cause death. Call your doctor for medical advice about side effects.
better.
You have a higher chance of getting pancreatitis if
You may report side effects to FDA at 1 -800-FDA-
• If KALETRA is being used for your child, tell your
you have had it before. Tell your doctor if you have
1088.
doctor if your child’s weight changes.
nausea, vomiting, or abdominal pain while taking
• KALETRA should not be given one time each day in
How should I store KALETRA?
KALETRA. These may be signs of pancreatitis.
children. When giving KALETRA to your child, give
• Increases in certain fat (triglycerides and
KALETRA tablets:
KALETRA exactly as prescribed.
cholesterol) levels in your blood. Large increases
• Store KALETRA tablets at room temperature,
• KALETRA oral solution contains a large amount of
of triglycerides and cholesterol can be seen in blood
between 59°F to 86°F(15°C to 30°C).
alcohol.
test results of some people who take KALETRA.
• Do not keep KALETRA tablets out of the container
o If a young child drinks more than the
The long-term chance of getting complications
it comes in for longer than 2 weeks, especially in
recommended dose, it could make them sick from
such as heart attacks or stroke due to increases in
areas where there is a lot of humidity. Keep the
too much alcohol. Contact your local poison control
triglycerides and cholesterol caused by protease
container closed tightly.
center or emergency room right away,
inhibitors is not known at this time.
KALETRA oral solution:
o Talk with your doctor if you take or plan to take
• Diabetes and high blood sugar (hyperglycemia).
• Store KALETRA oral solution in a refrigerator,
metronidazole or disulfiram. You can have severe
Some people who take protease inhibitors including
between 36°F to 46°F (2°C to 8°C). KALETRA oral
nausea and vomiting if you take these medicines
KALETRA get new or more serious diabetes, or high
solution that is kept refrigerated may be used until
with KALETRA.
blood sugar. Tell your doctor if you notice an increase
the expiration date printed on the label.
in thirst or urinate often while taking KALETRA.