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John Clark, LMT
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AZT and Interferon-alpha
for KS
Gay men with Kaposi’s sarcoma benefit
from a combination of AZT and interferon-
alpha, say doctors at the National Institutes of
Health. This combination of drugs reduced
the size of tumors for 11 out of 22 PWAs, and
the amount of HIV decreased for eight out of
22 PWAs. However, this drug combination
also increased the frequency of side effects.
Doctors at the NIH recommend that PWAs
with Kaposi’s sarcoma receive long-term
therapy with AZT (100 mg every four hours)
and interferon-alpha (5-10 million units).
Reference: J. Kovacs and others. "Combined
Zidovudine and Interferon-alpha 7 herapy in
Patients with Kaposi Sarcoma and AIDS."
Annals of Internal Medicine, August 15,1989,
pp: 280-87.
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SANDRA
K.
PINCHES,
Ph.D.
Counseling and Psychotherapy
1809 N.W. Johnson, Sie. 7
Portland, OR 97209
Specializing in issues of: (5°3) 227 7558
• Recovering Alcoholics • Lesbian & gay couples
• Co-dependency
• Intimacy & commitment
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just out ▼ 6 ▼ October 1989
BY J E F F R E Y
ZURLINDEN
Antibodies may speed infection
Scientists question whether certain
antibodies to HIV actually help the virus to
infect new cells. These enhancing antibodies
may allow HIV to enter white blood cells that
have few of the usual entry sites for HIV.
Enhancing antibodies may temporarily in
crease the rate of infection of new cells by
tenfold. Before vaccines can be tested,
researchers plan to fully identify the effects of
enhancing antibodies.
Reference: D. Bolognesi. "Do Antibodies
Enhance the Infection of Cells by HIV."
Nature, August 10,1989, pp: 431-32.
New testing begins for
AIDS drug
Immunoadhesin, a new drug to fight HIV,
began testing last month. This new form of
soluble r-CD4 combines the part of the T-cell
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that attaches to HIV with an antibody that
activates killer cells to attack HIV. In total,
3040 people will receive this experimental
drug. Scientists hope that immunoadhesin
will find HIV-infected cells and activate the
infected person’s immune system to kill HIV.
These initial clinical trials will be conducted
by the U.S. National Cancer Institute, New
England Deaconess Hospital, San Francisco
General Hospital, the University of
Washington, and Stanford University.
• Reference: C. Ezzell. "AIDS Closer to
Becoming a Treatable D is e a s e Nature,
August 24,1989, p: 581.
New AZT studies
Dr. Anthony Fauci announced in August
that AZT benefits otherwise healthy people
who are infected with HIV, but little was said
about the studies that led to the
recommendations. These recommendations
are based on a two-year study of 3,200 people
— one-third of whom received low doses of
AZT (500 mg daily), one-third who received
high doses of AZT (1,500 mg daily), and the
remaining third who received placebo (no
AZT). Among the people taking placebo, 38
progressed to AIDS or severe ARC. Only 17
who received low doses of AZT and 19 who
received high doses of AZT progressed to
AIDS or ARC. The researchers concluded
that low doses of AZT (500 mg daily) delay
the onset of ARC and AIDS among people
with fewer than 500 helper T-cells. Although
AZT can cause severe side effects in PWAs,
only 3 percent of the healthy HIV-infected
people in this study developed side effects.
These people reported only mild side effects
— usually limited to nausea. The study will
continue to determine if people with more
than 500 helper T-cells also benefit from
AZT.
Reference: J. Marx. "Wider Use of AIDS
Drugs Advocated." Science, August 25,1989,
%
p: 811.
Few cases of HIV-2 in United
States
So far the CDC has reported only six
people in the United States who are infected
with HIV-2, a close relative of HIV-1 that
also leads to AIDS. All six people
immigrated from Africa. HIV-2 is probably
spread in the same way as HIV-1, and the
CDC recommends the same precautions to
prevent infection with either virus.
Reference: CDC, "Update: HIV-2 Infection-
US." MMWR, August 25,1989, pp: 572-80.
CRONE MAGIC
249-0444
12-7 MON.-SAT.
1405 NE BROADWAY
PORTLAND, OR 97232
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